Mouse model database

Methods and results: To induce endothelial dysfunction, Nω-nitro-L-arginine methyl ester, a nitric oxide synthase inhibitor, was administered to C57BL/6 mice. Jun 14, 2018 · The rationale for this study is based on preclinical data from a mouse model combining stereotactic radiation therapy and a PD1-blocking antibody, which found that mice receiving the combination The Mouse Genomes Project uses next generation sequencing technologies to sequence the genomes of key laboratory mouse strains. Examples: Fmr1 Pax* Dnah5,Dnah6,Dnah7*. The National Institutes of Health has funded The Mouse Phenome Database is a collaborative standardized collection of measured data on laboratory mouse strains and populations. You can search single genes, a list of genes Jun 12, 2024 · Informative Gene Names Initiative. For mutations that have not yet been cloned, the loci are listed as "Unknown" at the bottom of the table. Nonetheless, mice and humans have evolved in and become adapted to different environments and so, despite their phylogenetic relatedness, they have become very different organisms. Contacts. Since its inception 25 years ago, MGD has served as the authoritative source for mouse genes, genome features, mutations and strain nomenclature. In support of this effort, we have collected information about core AD-related phenotypes and created Mouse Mutant Resource: Available mouse models. The Genomic study of parental mice database allows you to search gene expression in 6 key tissues (islet, liver, adipose, hypothalamus, gastrocnemius and soleus) as a function of genetic obesity (lean vs. 04–0. Benefits of using the Tumor Biology Database include: Freely access continuously updated, quality data from this extensive database to enable more informed drug discovery and development study decisions. Search and filter through a vast database of gaming mice. May 28, 2024 · Informative Gene Names Initiative. Similarities and differences between mouse and man in relation to studies on ageing have been reviewed (Vanhooren and Libert, 2013). MGD is the primary source for official gene, allele, and mouse strain nomenclature based on the guidelines set by the International Committee on Standardized Nomenclature for Mice. Mouse Models of Human Cancer Database Jan 1, 2019 · INTRODUCTION. org Voice: 207-288-6765 Fax: 207-288-6132. To facilitate use of mouse as a model in translational studies, MGD maintains a core of high-quality curated data and integrates experimentally and computationally generated data sets. The laboratory mouse is used extensively as a model for investigating the etiopathogenesis of human disease. fumigatus, and D. Coordinated by the International Mouse Phenotyping Consortium (IMPC), an international coalition will produce and phenotype a total of 5,000 knockout mice by 2016. The NHLBI-funded MOD is the Rat Genome Database. The Mouse Models of Human Cancer Database (formerly, the Mouse Tumor Biology Database) supports the use of the mouse as a model system of human cancers by providing access to information on and data for: spontaneous and induced tumors in mice. Nov 1, 2017 · The Mouse Tumor Biology (MTB) database is an expertly curated, comprehensive compendium of mouse models of human cancer. Meticulous curation and collaboration with data 25,570. genetically defined mouse models of cancer (inbred, hybrid, mutant, and genetically engineered strains of mice) Patient Derived Xenograft (PDX) models. Jan 1, 2003 · The Mouse Genome Database (MGD) provides an integrated view of genetic and genomic information for the laboratory mouse ( 1 ). The Mouse Genome Database (MGD) is the community model organism knowledgebase for the laboratory mouse. TS 25 (17 dpc) Digits joined together; skin wrinkled. However, data considering the relevance of these autoantigens in human AIH are scarce. Below is a list of mutation-bearing strains characterized since 2003, listed alphabetically by gene. HCC is the most common type and accounts for more than 90% of cases, and the other, iCCA, is about 10%–15% ( 1 ). Mar 16, 2023 · The role/s of sex hormones influencing asthma and AHR is yet to be fully elucidated however, there is observational data demonstrating that estrogen receptor β knockout male and female mice have increased AHR in a mixed allergen (ovalbumin, A. (2016) reported generating a nephrin-promoter-driven EGFP transgenic mouse model; they further showed that cultured glomeruli from this model serve as tools to screen for compounds that enhance nephrin-promoter activity. The use of genetically defined inbred mouse strains, humanized mice, and gene knockout mice has allowed the research community to explore how pathogens Using high-resolution ex vivo diffusion tensor imaging (DTI), we investigated microstructural changes in the white and grey matter in the P301L mouse model of human tauopathy at 8. Nov 11, 2017 · The model summary table on the MTB home page lists counts of mouse models in the database for the most common types of human cancer (Figure 1). Feb 28, 2024 · Here we established the Lung Cancer Mouse Model Database (LCMMDB), an extensive repository of 1,354 samples from 77 transcriptomic datasets. MGD develops and supports an integrated representation of mouse Jun 1, 2024 · Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) MGI: the international database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data for researching human health and disease. Mar 25, 2011 · We established a role for Prn in the mouse model by showing that a Prn knock-out (Prn-ko) mutation reduced colonization in trachea and lungs. Jan 8, 2019 · For example, Tsuchida et al. Get discounts on gaming gear and support EloShapes! Contact. More … Example searches: Disease, Region and Phenotype, Multiple Genes Mice are small and relatively economical to maintain, making them the ideal laboratory animal model. JAX Mouse Mutant Database is a comprehensive online resource for mouse models of human diseases. The KOMP Repository collection will provide investigators with the convenience of a one-stop portal to one of the largest inventories of mutant mouse strains and ES cell lines available to the biomedical research community. MMdb contents are freely accessible to all visitors and are not password protected. Restoration of the mutation resulted in a significant increase in colonization compared to the knock-out mutant. Conditional knockouts, and reporter strains. The UCSF Mouse Inventory Database is a central online resource for users to search for mice currently housed at UCSF. OB/OB), strain (B6 vs. 100 ng/µl mRNA Cas9 was mixed with 20 ng/µl of each of 44C1, 44C2, 45C2, 45C3 gRNAs (sequences in Supplemental Table 2) produced via in vitro transcription. For more infor email: admin. 256. The mouse is the foremost mammalian model for studying human disease and human health. Access the most cutting-edge models for AD including those overexpressing APP, Presenilin, and/or tau, and more. 3b) with basic information about the particular mouse model, such as mouse model name, modeled disease, model type, promoter, transgene and the reference of the original description of the model. MGI is the authoritative source for Feb 1, 2016 · It was then shown that this mouse is a poor genetic and phenotypic model of the human condition (Hatzipetros et al. Quickly and easily find model (s) and related information for your project, including: Genotypic and phenotypic data for tumor strains. The mouse is small, making it an economical choice, and it also breeds very well. Oct 29, 2015 · From within the “Models” tab, the user is able to select a model, which will present a detailed mouse model page (Fig. The advantages and disadvantages of the three types of experimental mice models will be discussed in this review. Jan 1, 2017 · The Mouse Genome Database (MGD) is the key knowledgebase for integrated and comprehensive access to genetics and genomics data for the laboratory mouse, with a primary goal of facilitating the use of the mouse as a model system for understanding human biology and disease ( 1, 2 ). Keywords: Knockout mouse, gene targeting, stem cells, Oncogene, tumor suppressor gene. Live. e. To truly utilize the power of the mouse as a model system, disparate data must be brought into a common framework. org) component provides mouse cancer model data to aid in selection of appropriate strains for experimentation, and provides the ability to review and compare tumor incidence and patterns of mutations in specific cancer models. infrafrontier. Nov 9, 2018 · More recently, with data from the Human Genome Project and sequencing of the Mus musculus genome showing remarkable genetic homology between these species, as well as the advent of biotechnology and the development of myriad knockout and transgenic mouse strains, it is clear why the mouse has become the most ubiquitous model organism used to Apr 14, 2023 · In 2019 the database name was changed from the ‘Mouse Tumor Biology database’ to the ‘Mouse Models of Human Cancer database’ to better reflect the translational and clinical relevance of mouse models. Information in MGD is obtained from diverse sources, including the scientific Jul 7, 2017 · The tumor model data offering within the MGI Resource (Mouse Models of Human Cancer: The Mouse Tumor Biology Database (MTB) 2016) includes data on mouse models of cancer from studies on spontaneous and induced tumors in genetically defined mice (inbred or genetically modified), accompanied by the tumor frequencies observed, diagnoses and A web- and programmatically-accessible data service for typed, sequenced, and imputed allelic state data for 657 strains at 106. MGD contains information on mouse genes, genetic markers and genomic features as well as information on molecular segments (probes, primers, cDNA clones, BACs and YACs) mutant phenotypes, comparative mapping data The laboratory mouse is the premier animal model for studying human biology because all life stages can be accessed experimentally, a completely sequenced reference genome is publicly available and there exists a myriad of genomic tools for comparative and experimental research. MGD curates and provides functional and Nov 9, 2011 · INTRODUCTION. In 2020, the look and feel of the website was overhauled, and advanced search capabilities using faceted search interfaces were implemented. Meticulous curation and collaboration with data Jan 1, 2019 · ABSTRACT. Although PITT strategies have overcome the limitations of random transgenesis, a major pitfall Nov 29, 2006 · The mouse genome database (MGD) is a comprehensive, integrated system for exploring genetic, genomic and biological information for the laboratory mouse ( 1 – 3 ). Scientists have amassed tremendous knowledge about mouse physiology, anatomy, and its genes, stemming from more than 100 years of working with them. Database. Over the past 30 years, mouse molecular genetics has been refined to allow production of an Oct 29, 2008 · This review focuses only on the available mouse models for HCC research, because of the existence of a broad range of (i) chemically induced models, (ii) xenograft models and (iii) genetically modified models, in mice. Mouse models are important tools both for studying the pathogenesis of infectious diseases and for the preclinical evaluation of vaccines and therapies against a wide variety of human pathogens. Jan 1, 2021 · INTRODUCTION. org Mouse phenotyping studies analyse biological properties, such as the evolution of disease symptoms, in mice that have had a specific gene modified, added or removed. The Alliance was established to provide a common infrastructure and searchable software platform for all the NIH Mar 15, 2022 · Overall, the model-based meta-analysis approach presented herein enabled cross-study comparison of efficacy in the RMM and provided a framework whereby data from emerging studies may be analyzed in the context of historical data to aid in selecting candidate drug combinations for clinical evaluation as TB drug regimens. Also includes protocols, projects and publications, and SNP, variation and gene expression studies. A variety of different model organisms are used in this regard, but mice are especially useful because they share mammalian features with humans and suffer from many of the same diseases. TS 26 (18 dpc) Long whiskers. Utilize JAX Amyotrophic Lateral Sclerosis mouse models to research sporadic and familial ALS. TS 28 (postnatal; P4-adult) Postnatal development. Includes baseline phenotype data sets as well as studies of drug, diet, disease and aging effect. MGD data content includes comprehensive characterization of genes and their functions, standardized descriptions of mouse phenotypes, extensive integration of DNA and protein sequence data, normalized representation of genome and genome variant information including comparative data on mammalian genes. I look forward to hearing from you! Jan 8, 2021 · Uniformly processed RNA-Seq data are imported from the EBI Expression Atlas and then integrated with the other types of expression data in GXD, and with the genetic, functional, phenotypic and disease-related information in Mouse Genome Informatics (MGI). Researchers leverage these models to screen candidate therapeutics through the consortium’s Preclinical Testing Center using rigorous Jun 1, 2024 · Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) MGI: the international database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data for researching human health and disease. They have proven to be useful in validating gene functions, identifying novel cancer genes and tumor biomarkers, gaining insight into the molecular and cellular mechanisms underlying tumor initiation and multistage processes of Dec 9, 2016 · The Mouse Tumor Biology Database (MTB, www. TISMO contains 605 in vitro RNA-seq samples from 49 syngeneic cancer cell lines across 23 cancer types, of which 195 underwent cytokine treatment. Mouse Models of Human Cancer Database (MMHCdb) MMHCdb is a comprehensive, expertly curated resource of diverse mouse models of human cancer. TS 27 (newborn; P0-P3) Newborn mouse. Overwiew publications: Jan 8, 2024 · To model the gene fusion in the mouse genome, double-strand DNA breaks were generated in the first introns of Rlf and Mycl by infecting RPR2; Rosa26-LSL-Cas9 mice with a lentiviral vector that Mar 24, 2020 · The Jackson Laboratory is the exclusive service provider for robust, reliable, reproducible gene therapy, efficacy, and safety studies in the C9orf72 mouse model, the most common form of familial ALS. Visit the Mouse Feb 29, 2024 · Here we established the Lung Cancer Mouse Model Database (LCMMDB), an extensive repository of 1,354 samples from 77 transcriptomic datasets. • Mouse Models of Human Cancer MMHCdb provides information on the frequency, pathology, and genetics of spontaneous and induced tumors in mice. May 21, 2016 · Abstract. UCSF Mouse Inventory Database. Generation of hDMD del45 mice. This example illustrates how relevance to the human disease being studied, supported by strong data to validate the use of the model, is crucial for clinical translation. And the mouse genome is easily manipulated in order to create even more precise Feb 28, 2024 · Here we established the Lung Cancer Mouse Model Database (LCMMDB), an extensive repository of 1,354 samples from 77 transcriptomic datasets covering 974 samples from genetically engineered mouse models (GEMMs), 368 samples from carcinogen-induced models, and 12 samples from a spontaneous model. Mugen mice, Gene, Model of Human Disease, Model of Immune Processes, Transgenic Tool) on the homepage or via the search option, available Compare. After the base is put into operation, SMOC’s capability to provide genetically modified rat/mouse models and technical services including gene function research and drug development will be greatly enhanced. There is a large, ongoing effort to characterize disease models in order to better understand pathophysiology as well as to identify models suitable for investigating potential therapeutics. The page with model details Sep 18, 2019 · Mouse models are important tools both for studying the pathogenesis of infectious diseases and for the preclinical evaluation of vaccines and therapies against a wide variety of human pathogens. The relative proportion of the "state" in which mouse resources are maintained across all repositories (not a measure of unique strains). Sep 15, 2023 · Insufficient Anatomic Pathologists to Characterize and Review Mouse Model Pathology Data. The Knockout Mouse Program (KOMP2) is an NIH initiative that, together with the other members of the International Knockout Mouse Consortium (IKMC), aims to generate a public resource comprised of knockout information for all protein-coding genes in the mouse genome. For the gene (s) specified above return all SNPs: within the gene (s)include 2 kb upstream and downstream of the gene (s)include 10 kb upstream and downstream of the gene (s) Jun 3, 2019 · A humanized triple-knockout BLT mouse model lacking the RAG-2 recombinase component, the γ-chain of the IL-2 receptor and the signal-regulatory protein CD47 (Rag2 –/– Il2rg –/– Cd47 Jul 27, 2015 · Data integration is an underlying principle for MGD. Ovaries. Jun 12, 2024 · Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) GXD collects and integrates the gene expression information in MGI. Over the past decade, new methods and procedures have been developed to generate genetically engineered mouse models of human disease. Oct 26, 2021 · The Mouse Genome Informatics (MGI) database system combines multiple expertly curated community data resources into a shared knowledge management ecosystem united by common metadata annotation standards. MGI’s mission is to facilitate the use of the mouse as an experimental model for understanding the genetic and genomic basis of human health and disease. , 2014). Anatomic Pathology is the mainstay of clinical diagnostic pathology and is essential for the accurate diagnosis of disease, even in the molecular era. Through the enforcement of nomenclature and related annotation standards, MTB supports aggregation of data about a cancer model from diverse sources and assessment of how genetic background of a mouse strain influences the May 25, 2022 · Here, we introduce MusMorph, a database of standardized mouse morphology data generated with an open-source, atlas-based phenotyping pipeline that integrates techniques from image registration Jun 12, 2024 · Gene Symbol/Name: Search Current symbol (mouse or homologs) Current symbol (mouse) Current symbols/names, synonyms & homologs. Jan 11, 2023 · MODEL-AD teams have used genetic, molecular, clinical, and imaging studies to generate and deeply characterize more than 50 mouse models of late-onset Alzheimer’s, the most common form of the disease. Here, we About KOMP. MGD contains comprehensive information about mouse gene function, genotype-to-phenotype annotations, and mouse models of human disease ( 1 ). This At a Glance article highlights several recent technical advances in mouse genome manipulation that have transformed our ability to manipulate and study gene expression in the mouse. Abstract. informatics. BTBR), and age (4 vs. The use of genetically defined inbred mouse strains, humanized mice, and gene knockout mice has allowed the research community to explore how Apr 9, 2019 · GEO help: Mouse over screen elements for information. The IMSR is a searchable online database of mouse strains, stocks, and mutant ES cell lines available worldwide, including inbred, mutant, and genetically engineered strains. The ability of clinical isolates with different Prn variants to colonize the mouse lung was Dec 16, 2011 · The mouse is the model of choice for recapitulating genetic changes that give rise to human disease. Here you can find links to databases for mouse genomes and other resources. Mouse gene symbols link to gene information in the Mouse Genome Informatics (MGI) database. For more details, see the NIH KOMP2 Home Page. The relevance of laboratory mouse to biomedical research includes its extensive experimental genetics capabilities, fully-sequenced inbred strain genomes, published genotype to phenotype associations, and data for genome wide coverage of induced variation from mouse large Jul 19, 2023 · The detailed, exploitable, and quality-controlled information present in the INFRAFRONTIER database is available on the INFRAFRONTIER website (www. Get in touch with EloShapes. eu), where users can access integrated mouse strain data, search the database, and explore archiving and distribution services along with dedicated disease model resources (described May 14, 2024 · Here we established the Lung Cancer Mouse Model Database (LCMMDB), an extensive repository of 1,354 samples from 77 transcriptomic datasets covering 974 samples from genetically engineered mouse models (GEMMs), 368 samples from carcinogen-induced models, and 12 samples from a spontaneous model. You can view our models across a range of different histotypes that closely mimic the respective clinical disease. The Knockout Mouse Project (KOMP) is providing critical tools for understanding gene function and the genetic causes of human diseases. Meticulous curation and collaboration with data depositors have produced a robust and comprehensive database, enhancing the fidelity of the genetic landscape it depicts. We then used the Japanese Adverse Drug Event Report database to investigate the role of pitavastatin in preventing the onset of aortic dissection. The Mouse Genome Database (MGD) serves as a primary resource for mammalian biologists, delivering a spectrum of genetic, genomic and biological data supporting the use of mouse as a model for understanding human biology and disease. **Only available on the UCSF network/VPN. The integration of data from many sources requires applying common semantic standards across those data. Diseases are assessed at both a macroscopic (gross) and microscopic (histopathologic) level. Genetically engineered mouse models have significantly contributed to our understanding of cancer biology. farinae) model compared to wild type mixed allergen alone (Kalidhindi May 28, 2024 · The Human - Mouse: Disease Connection (HMDC) is designed to facilitate the identification of published and potential mouse models of human disease, the discovery of candidate genes and the investigation of phenotypic similarity between mouse models and human patients. 8 M locations. 08pg each gRNA) was injected into the nucleus with Jun 30, 2022 · Keywords: hepatocellular carcinoma, mouse model, gene-edited mice, metastasis, transplantation model. Three weeks later Aug 12, 2014 · Mouse models for type I AIH are not described, but inducing autoimmunity against PD-1 and/or IL-4R in C57BL/6 mice is a possible option. Its primary emphasis is on endogenous gene expression during mouse development. 2–0. In addition, the ease of maintaining and breeding mice in the laboratory, the availability of many inbred strains, and more importantly the possibility of precisely manipulating the Feb 13, 2012 · Data accumulated to date suggest that NOG/NSG mice are the best recipients for humanized tissue and human A new humanized mouse model of Epstein–Barr virus infection that reproduces Oct 11, 2007 · DATABASE AVAILABILITY. These newly acquired mouse and ES cell lines have been deposited into the MMRRC at UC Davis. Aug 5, 2021 · Measurement(s) brain measurement Technology Type(s) magnetic resonance imaging (MRI) Sample Characteristic - Organism Mus musculus Machine-accessible metadata file describing the reported data Alzheimer's Disease Commonly Used Mouse Models. The table displays mouse models where the tumor type is reported at a frequency of ≥80% in a colony/study size of ≥20 mice. It provides detailed information on spontaneous, induced and engineered mutations, as well as phenotypic and genotypic data. An acute or chronic deficiency in Treg function or number may be necessary to induce severe AIH. MGD maintains a unified catalog of genes and genome features, including functional RNAs, QTL and phenotypic loci. This editorial is an overview of the development and applications of mouse models of cancer and directs the reader to upcoming papers describing the use of these models to be published in coming issues, beginning with three articles in the current issue. genetically defined mice (inbred, hybrid, mutant, and genetically engineered strains of mice) in which Jun 12, 2024 · Mouse Gene Expression Data Search. Jan 1, 2015 · The Mouse Genome Database (MGD, ) ( 1 – 3) serves the international research community as the central resource for integrated genomic, genetic and biological data on the laboratory mouse. Users can search, browse and compare mutant strains, and access protocols and publications. MGI provides access to integrated data on mouse genes and genome features, from sequences and genomic maps to gene expression and disease models. For unbiased computational analysis, we implemented a pipeline for voxel-based analysis (VBA) and atlas-based analysis (ABA) of DTI mouse brain data. MGD facilitates the study of human biology and disease by supporting the mouse as an exquisite model system and enables hypothesis generation through its integration of diverse . Compare the shapes and technical specifications of gaming mice. CRISPR/Cas9 injection into hDMD zygotes was performed by the University of California, Davis, Mouse Biology Program. There is no need for visitors to login upon entering MMdb; on the contrary, they may browse the available data by clicking on the available links (i. Dec 1, 2016 · However, what makes the mouse an attractive model for studying mammalian biology is the genetic manageability of its genome, ease of breeding, and the large amount of available baseline phenotypic data. Jan 1, 2018 · INTRODUCTION. The project consists of two arms: Short-read sequencing of many laboratory mouse strains and identification of sequence variation (SNPs, short insertions and deletions, and larger structural variations) relative to the Jun 7, 2024 · A mouse model is a laboratory mouse used to study some aspect of human physiology or disease. Leverage JAX expertise with the Cre-lox system to generate knockouts. Affiliates and Discounts. Jan 1, 2022 · TISMO provides web interfaces to help users explore the syngeneic mouse model data interactively. Thousands of laboratory mouse strains are now available, so scientists can therefore choose the ideal mouse model to study different diseases and disease processes. tumor. 10 weeks), in our mouse model of Type 2 diabetes. “All the institutions involved follow an identical protocol for mouse phenotyping, meaning we can Mouse model database is a bank of potential Jan 7, 2022 · We present Tumor Immune Syngeneic MOuse (TISMO), a database with an extensive collection of syngeneic mouse model profiles with interactive visualization features. 5,591. The mission of the MGD is to advance the use of the laboratory mouse as a model system Jan 8, 2021 · MGD is the authoritative source for biological reference data related to mouse genes, gene functions, phenotypes and mouse models of human disease. A large number of mouse models have been created to target Mar 14, 2023 · The six NHGRI-funded MODs/data resources are: Mouse Genome Database, WormBase, Zebrafish Information Network, Saccharomyces Genome Database, Flybase, and the Gene Ontology Consortium. mousedatabase@ucsf. alternata, A. The use of mice as model organisms to study human biology is predicated on the genetic and physiological similarities between the species. There are two major types of primary liver cancer, hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA). 2–4pL (0. jax. In the current era o … mouse model research. 5 months of age. We focus on: spontaneous and induced tumors in mice. E-mail: nomen@jax. Apr 2023. Despite this, the molecular events that influence NASH pathogenesis remain poorly understood. edu. In summary, TISMO is a comprehensive database of syngeneic mouse models that will help users select relevant syngeneic mouse tumor models, provide data to generate and test hypotheses, and reveal novel mechanisms of ICB response and resistance. The Cancer Model Database includes tumor models from a wide range of tumor subtypes, including patient-derived xenografts (PDX), cell line-derived xenografts (CDX), and mouse syngeneic models. Nov 3, 2008 · The Mouse Genome Database (MGD, ), integrates genetic, genomic and phenotypic information about the laboratory mouse, a primary animal model for studying human biology and disease. May 28, 2024 · Get recombinase (cre) activity data for knock-in and transgene alleles. Jan 1, 2019 · The mouse is a longstanding model organism for human biology and disease because of its relative phylogenetic closeness and physiological similarity to our species. OBJECTIVE: Nonalcoholic steatohepatitis (NASH) is closely associated with metabolic syndrome and increases the risk for end-stage liver disease, such as cirrhosis and hepatocellular carcinoma. el in mice using pharmacologically induced endothelial dysfunction. 4pg Cas9 and 0. See full list on informatics. The longstanding objective of GXD has been to capture and integrate different types of mouse developmental expression information, with a focus on endogenous gene expression in wild-type and mutant mice, and to make these data readily accessible to researchers via biologically- and biomedically-relevant searches. The implementation of the Mouse Nomenclature Guidelines is carried out at the Mouse Genome Database through the Nomenclature Coordinator. kh qb bo ys xy ak zq tt cw hm